Started using it recently for work and it has been reliable thus far. The only issue that I've had was when upgrade to Mojave where a patch was needed. But to do this you clone the nixpkgs repo (of package descriptions), cherry pick the fix, point the package manager to the repo, and it continues to work.
One can create docker images from the machine definitions, so the target need not be nixos, but anything that runs docker.
But if you're not the type of person to pull through difficulties then this distro is not for you (yet).