And your post also answers you sibling comment: Ctrl modifier is useful outside of just Emacs.
Try it out. I believe the API changed in the macOS release before Mojave, so they relaunched Karabiner under the name Karabiner Elements. This option is under the "Complex Modifications" tab.
If I was writing a list of tricks for macOS power users to try, this would be my number one. Up there with binding a global show/hide hotkey for iTerm (I use Ctrl-Space, thus CapsLock-Space).