Regarding NFS: I have recently started testing LMDB on NFS v4 and had no issues so far, but with a single process using the database. AFAIK the warning at http://www.lmdb.tech/doc/ is only for multiple processes using the DB concurrently. I am still not entirely sure there won't be any mmap-related issues, but so far so good.
Regarding "being careful": this is a very important point. The LMDB API does not hold your hand, it lets you do dangerous things which will result in corruption of your database, which you will discover too late. I suggest writing a wrapper around the API to ensure you are using it correctly. (I wish there was a compile flag like LUA_USE_APICHECK [1] for LMDB, which could help detect problems like this, but there isn't.)