On 17 October, there was a multi-AZ network failure at us-east-1. It only lasted 3m35s, but it was enough that our customers were calling about our site being down.
That's still just one region, unless you were also hosted outside us-east-1.
Just grabbed first article. Example: In this case capitalone went down. I don’t work at capitalone - but I imagine they had their data copied across every region 30 times.