And that's a huge problem. The notion of a "pixel-perfect design" doesn't belong on the web. In the case you mention, you're sacrificing accessibility for control over what your users see. You're kind of telling your users that you know what they want better then they do. That they should be able to read the small type you put in front of them, even if their eyes are bad.

CognitiveLens is right. Proportions matter.

(Note: when I say "you", I refer to the "one [who] wants a pixel-perfect layout" which may or not actually be you.)