At least from your post it seems to me like you're talking about something like the 50s. You need only go back a decade or two to see tremendous differences in rates of psychotropic prescription and usage. And the sheer numbers here mean that if these drugs are as having as large a positive effect as many users do believe them to be, then we should be able to see tremendous macro level positive indicators. But I'm not sure we really do. By contrast I could certainly point to sharp increases in a variety of physiological and psychological disorders which are considered side effects of these treatments.
[1] - https://fivethirtyeight.com/features/dear-mona-how-many-adul...