For example, I've met people (American and others) who weren't aware that the UK hasn't switched to the euro. I once pointed this out to two surprised Americans on a flight to London - when you are a few hours from landing this is more useful than knowing the prime minister's name!
Beyond knowledge and ignorance (there are certainly ignorant Brits too) there may be a difference in attitude which sometimes comes across as ignorance. I'm relocating from London to NYC in just over a week so it will be interesting to experience the differences, I've heard that despite being quite cosmopolitan NYC is generally a little more inward looking.