> CRISPR in individual humans sounds potentially great

Nuclease based editing with CRISPR is only going to be able to disable things in somatic tissues. You need to include exogenous DNA template in order to evoke precise allele changes, and that's really only possible in vitro.

What, you don't want to wipe out half the planet's ability to procreate in a single generation? (the genocidal maniacs and overpopulation buffs are going to be all over this, maybe, if one of them has the guts and the brains)