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Tobacco use kills 443,000 Americans each year.

That's "1 of every 5 deaths in US due to smoking," I've submitted it now:

Now how is then smoking less harmful than using some other substance? Or is the evaluation skewed somehow?

I'm pretty sure that data is about ten years old, but otherwise it's correct. Overall drug use kills about 1 in 3 Americans.

Tobacco at least only kills the person stupid enough to use it. Drunk driving kills thousands of innocent people.