I don't know how hard it would be but I've been thinking it would be cool to have a WebGL implementation in node. Desktop gl apps using webgl would sorta cool but dunno about real use cases.
And there's also a similar project, much further along, to put all of OpenGL in V8:
The v8-gl project is fairly different. I'm trying to emulate the whole WebGL API rather than just provide OpenGL bindings.