What are those?
As for runes, IIRC you couldn't buy them with the paid currency, Only with the currency earned from playing. It's a moot point since they merged runes and masteries anyways.
You don't have the same pool of characters as other players who've chosen to pay for their favorite champions and this is clearly a disadvantage.
This is different from games like, say, Overwatch, where the entire hero pool is available to everyone (different game, sure but the point stands).