You can fake it by setting low zoom level. Far from perfect, you won't have pixel perfect results, but you'll get general overview how layout gonna work.
If it's UHD (3840x2160) it's going to be exact. If it's actual 4K (4096 × 2160) then it won't be sharp at Full HD resolution (1920x1080) because the pixels don't align.
But many monitors have Marketing 4K which is UHD.
4K most commonly refers to 3840x2160. Which is of course not exactly 4000 pixels, but neither is 4096 :)