In working in tech and knowing the city inside and out. This is flatly not an issue.
Further, i used to live upper market at twin peaks - and taking the bus was not a problem other that the normal muni issues whoch this discussion is not about.
Ive biked and walked and commuted literally every area in sf. Lived twin peaks, presidio, biked and commuted all of down town marina etc.
Hills is a literal non issue.