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I wish PySide (and/or PySide2) would work with PyPy. It looks like (after a cursory search) some version of Gtk can be used but I prefer Qt over Gtk.

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For gtk, gstreamer etc. PyGObject should just work. It has PyPy as part of its CI pipeline. Also in combination with matplotlib (GTK3Cairo backend) and numpy.

Not sure about PySide2..

Thanks, but I mentioned I don't want to use Gtk. I've not had a particularly joyous time with Gtk in the past and therefore chose Qt as my GUI platform of choice over Gtk.

Therefore until and unless PyPy has usable Qt bindings (e.g. PySide or PyQt), then unfortunately I need to stick with CPython :/

Yeah, sorry. It shows at least that it's possible with the current PyPy C API layer to have GUI bindings working.

Here is the only PyPy related issue I found for PySide2: https://bugreports.qt.io/browse/PYSIDE-535

PyQt doesn't have a bug tracker ¯\_(ツ)_/¯

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