Here's what I did about it:
1. I asked the most attractive & wonderful girl out on a date. Mind you, I am a geeky programmer and nobody's going to mistake me for a sex icon anytime soon. Nevertheless, she was impressed by my boldness and said yes. Now we're married with three kids.
2. I started a company as CEO. It failed. But being CEO stretched me into a new role and I grew immensely.
3. I'm now working on a project that I think has a huge potential for positive impact on the world. I'm not motivated by money or glory this time around, but just want to see if I can grow and pull it off.
I guess to sum it up: know what you want out of life and then be bold and take risks.