* The blocking engine operated by either Safari or Chrome is a black-box and independent devs will have a harder time understanding it, tweaking it, improving it, debugging it.
* Chrome devs are now playing nicely and get feedback and propose some improvements to the APIs but there is no warranty this will happen again, or that they will invest time/energy in the future improving this part of the browser.
* It's harder to work with this API than a JavaScript code-base you control.
* Chrome seems a bit better here but for Safari the documentation is pretty poor.
* You also don't get feedback regarding the rules which matched on a page and this makes it harder to debug or give nice insights to users.
That's only a few points from my personal experience but I discussed multiple times with developers of other privacy-enhancing extensions/apps and we shared similar feelings.