create-react-app is a complex tool put together by I team I largely trust. What I want on my machine is a static build of their work, not the whole sausage making factory in 1568 pieces. Once I would have the binaries, the whole of npm and the JavaScript ecosystem could go away altogether and I would still be able to build and deploy my apps.
The package, in its published form, would be vetted by the create-react-app, who have a much better idea of what's going on in their dependency tree than I do. If they decided they need that many dependencies, it is up to them to manage the complexity. That said, it would probably make their lives easier to depend on 10-20 packages, statically built by people they trust, and so on.
Even if the result of this would initially be very similar to today (still running the same code of those 1568 packages), it would make me trust this stack a lot more.