PySide2 makes this way easier. I recently setup a PySide2 Project in PyCharm with the integrated package-management and it was a breeze (I guess the official support helps a lot as opposed to PySide[1]). First tried several other graphical libraries and was getting nowhere, but was happy that the Qt integration was relatively painless.

On a related note, does anyone know of a way of creating a "stand-alone binary" or installer for PySide2?