I'll add to this by saying that going on zoloft a year ago has been like the best nootropic experience of my life. In many ways, the first 6 months were like a persistent 24/7 microdose on MDMA ..... it was incredible. I also turned my life around and accomplished some of my life's most impressive work, all while not trying to kill myself anymore!
Beyond solving a massive sudden depression, it was actually quite enhancing. I felt like I was in the movie limitless. Given the pathways SSRIs target in the brain, I'd say they have similar benefits to all of that SV legacy around psychedelic use....
Sadly, things normalized and the burst of awesome tapered off. Now the medication is the new normal, and skipping doses brings the depression back, just not nearly as bad as it was. Hopefully some day we will learn how to tweak it so the immensely positive experiences last forever.
These days, I no longer think of antidepressants as any kind of crutch. If anything, it is another tool in the transhumanists toolbox allowing the human body to perform better than nature has provided.