If you don't want to use C (I don't blame you if you don't) you could use Cython or Numba. And certainly in my number crunching code the amount of code that actually crunches numbers, and thus could really benefit from being written in a GIL releasing way, is really quite small.

No you can still use pure Python, and use multiple threads, and get concurrency just fine. The global lock doesn't stop you doing that! C extensions being able to release the lock is just a bonus on top.

Lots of problems are merely I/O related, which can be solved just fine with Python threads. As for number crunching (let's assume that means CPU intensive tasks), you can always still resort to multiprocessing (which can also be combined with multithreading, I fail to see why such paradigms cannot be combined).