Coding the whole app in JS in the browser and using the server only for proxying data and validation/filtering.

See: SproutCore, Cappuccino, Backbone.js, JavaScript.MVC

Avi Bryant's "Django is obsolete, but so is everything else"

http://python.mirocommunity.org/video/1186/djangocon-2009-dj...

Yehud Katz's

http://yehudakatz.com/2010/09/14/heres-to-the-next-3-years/