I've had bugs popup on the weekend or during a vacation (and I do travel with my laptop everywhere I go). 99% of the time they fall into the 'we can live with that until Monday' category. My relationship with my wife and friends is simply too important to let something as trivial as a startup get in the way of it.
I just can't help but feel like we're continuing to romanticize this workaholic culture. That somehow to be a 'real' entrepreneur you have to turn your whole life over to it.
This is one place that I agree with the guys from 37 signals. You don't have to kill yourself to make a business go. You don't have to work 80 (or 120) hour weeks.
Starting a business is a marathon, and like all marathons it requires pacing. A large part of that is learning to separate the real emergencies from the perceived ones. Just because something isn't working, it doesn't mean that your business will fall over if it continues not to work for 48 hours. That sort of triage is really important if your going to maintain your sanity to get to the fourth year.
Just how I see it at least. My wife would certainly write a very different article than this one.