It's all about knowing the best places for modifier keys; Control next to A, Caps Lock encased in concrete at the bottom of the Marianas Trench.

I learned Emacs[0] on a Symbolics "space cadet" keyboard which has all the modifier keys in the lower left corner. Maybe that's why I've never felt any need to move the control key from its lower left location on my Mac keyboard.

[0] Technically Zmacs, but most of the key bindings were the same.

HARD CORE Emacs users remap Space and Control! ;)