I'm running Arch, which I find to be the most frictionless when you're trying to do sort of "bleeding edge" stuff like this.
Edit for a little more detail: I used Ubuntu for a long time on my desktop and actually did quite a bit of gaming on it. Mostly stuck to games that have native Linux support but from what I hear the compatibility layer that Valve has released is actually really good. If gaming is your thing.
All this is to say, things that were once supposed to be impossible on Linux are now very much possible.