Unfortunately it's a pretty manual, tedious and frustrating process, especially when the code is minified and you want to squeeze it into as small a source file as possible.

A generic (pseudo) quine is:

   s = "print escape(s)\n{payload}"
   print "s = "
   print escape(s)
   {payload}

So if you wanna do extra stuff on top of being a quine, just write that program and bootstrap with escape()

We don’t do this, that and the other thing because they are easy, we do it because they are hard.

The tedium is part of the difficulty. Making it easier is not inspirational. Although buildings the tooling to do so would itself be quite the challenge ...