I'm working on my first larger, industrial-strength REST API in Python and I've found the Django Rest Framework to be more suited once you get to that level of complexity.
django-rest-framework is nice because it's maintained well and it's consistent with the rest of Django, but plenty of people just prefer the Flask way of doing things, even if it's a scrappier set of tools in some ways.
FWIW, I don't like DRF's reliance on serializers that do more than serialization.
This may be biased (I've been a Flask user since 0.7), and perhaps I'm stuck in my ways, but I've found I either need to find a supported and blessed Django plugin for the thing I need, or build something much more complex than I'd need in Flask.
For a company as specialized as Netflix, they probably are doing so much customization it doesn't matter much which framework they started with.