As someone who has suffered from CFS for a long time, it is definitely not imaginary.
To say it’s purely physical is discounting the mental aspect of the disease. I personally suffered trauma as a child and I’ve seen first hand what strong negative emotions can do to the body.
I would think it unlikely that there will be a miracle drug that will cure it, I believe it is a disease of both the mental and physical.
For anyone affected by CFS and think that trauma may play a part, the book “The Body Keeps the Score” has helped me get more energy and control back.