I’ve never been worried about being fired for something. Not everyone makes huge fireable mistakes.
I have my own go-to example that I'll use if they give back your type of answer (which has happened). I messed up packaging a demo version of our software that almost sank a 300k sale (~5% of revenue on the P&L for that year).
Was I going to get fired? no Did 23 year old me think I might get fired? yes
Essentially it boils down to what's a large mistake you've made while employed (or otherwise) and how did you resolve it.