We are currently setting up GLPI + OCS Inventory NG because we couldn't find any other options that had good asset management. That being said, GLPI is clunky. It's not my first choice, but I couldn't find many options out there that integrated asset management.
I feel like as more and more web-based businesses grow, traditional help desk requirements are being left behind (perhaps helped by some organizations going BYOD). Bit jealous of all the people who need help desk software but don't need integrated asset management.