No, the big things are varying ear canal sizes and shapes, varying earplug sizes and shapes, and side sleepers.

Put an earplug in your ear that seals the ear canal, then press firmly on the outside of your ear canal (on the side of your head, in front of the tragus). Feel that pressure. Now imagine doing that for 8 hours a night.

I have had to sleep with ear plugs because of noise from neighbors. Two results: waking up with painful ear canals during the night, and semi-permanently enlarged ear canals, requiring the use of larger ear plugs to seal, which causes more pain.

If you can comfortably sleep with ear plugs with no adverse effects, you are lucky.