A friend and coworker of mine had a saying "Speed Kills" about trying too hard to make things fast while keeping the system robust. You most certainly can make more secure systems, as the merely superscalar and less intense CPUs are, but they're significantly slower.

All depends on your threat model; to take one extreme, if you're crunching numbers with your own optimized numeric code, the issue of untrusted code of "random JavaScript off the net" is not an issue. And I doubt many mainframes are used to casually browse the net ... I certainly hope not at the same time they run the night's financial transactions!