Once you grow big enough the EU will inevitably have leverage over you: Servers rented in the EU to lower latency, payment streams from EU customers, offices in the EU to get talent, subsidiaries created for tax reasons, executives on vacation, employees on conferences, money spent on advertising, etc.
If you are a startup in SV the EU migh not have much direct pressure it can apply, but how would an investor react when given the choice of "we could spend some more money now, or we could do nothing and be significantly limited once we grow to a certain size, basically unable to do anything significant in one of the largest economies of the world".