I don't have problems per se with "synthetic" materials, but I do respect that compounds introduced within the past few decades are more likely to have zany side effects than those which plants have evolved alongside for hundreds of thousands of years.
> Be it as it may, the danger will always be greater for farmers than consumers. Integrated Farming accounts for this as well, and the list of available pest management substances is constantly being updated. I don't know how well IF works in the US, but in the EU (Portugal) at least I get updates every now an then.
It seems to me that the disparity in danger can be reduced by backing out of the monoculture / dead soil / carpet bombing style of farming and adopting practices more in keeping with how these plants seem to want to grow.