I am still having trouble understanding the specific problem you want solved, and what an additional open drug database would add that DrugBank lacks but that is required to accomplish your solution.

It seems like your frustration is mostly with the Surescripts monopoly on electronic prescribing. You say that they dictate an approved commercial vendor. This is a very different problem, and would have very different solutions, than the problem We don't have any open source drug interaction database, which is where this thread started.