Some bits of github don't work unless you enable JavaScript, but most of it does. So I only enable it when I'm using those bits.
I also make sure I log out of github before I start browsing other websites.
* IE for two banks
* firefox+adblock for gmail, github and chesscube
* chrome for facebook
* opera for everything else, which includes HN.
Just looking back at that list makes it seem even more terrible than it actually is :(Don't get me wrong, I can appreciate reducing your attack surface... but noscript just doesn't seem like that great of an idea, still.
Humans are quite irrational sometimes...
I don't use the twitter.com website any more. Prefering to use clients that don't run JavaScript. Whenever I can use something other than a web browser to access a service, I will take that path. I use NoScript when that isn't an option.
I also found (and reported responsibly) an XSRF flaw in Linode.com a few months back that I believe has now been fixed. That was quite a dangerous one. I also found an XSS flaw in DuckDuckGo a few weeks back. Maybe this is the reason I'm so "paranoid" about JavaScript. Maybe I'm right to be.