Rigorous double blind a/b/c/d tests using real listeners has been performed, and the research has been published in peer reviewed journals since the 80's.
What has happened is that most of the audiophile community saw research as a threat to their revenue streams and actively FUD around it. And the audio engineering community has simply moved on.
Here is a talk that could be very informative. https://www.youtube.com/watch?v=zrpUDuUtxPM
His book is worth a read as well.