The big hitters are Drug addiction and Chronic Pain.
I don't have a solution for drug addiction, but I can't blame our generation for not finding a solution. No generation has, and given caffeine addiction, it's extremely hard for others to help with.
Chronic Pain needs to end. Between Doctors of Physical Therapy and medications, there are little reason for people to be experiencing chronic pain. Take note that the author was very generic about their meaning on that.
The rest of the stuff are significantly smaller and usually involved a traumatic event.
What can we do?