They're the leading cause of death among young people, and they take up massive amounts of space in our cities.
https://www.epa.gov/ghgemissions/sources-greenhouse-gas-emis...
Note that there are competing concerns and incentives here. Cities have other pressures which run other ways.
One of the best ways that cities can contribute to lowering CO2 emissions is to make it so that the city is designed in such a way that a car is not a mandatory requirement for travel.
Creating reasonably dense residential/commercial communities that are traversable by walking and active transportation instead of sprawling out to the horizon is how to achieve this.
http://spacing.ca/toronto/2016/05/26/induced-demand-housing/
Other concern: what are the effects of super-dense cities on mental health? Spread-out cities often have a lot more green, which I know has positive effects mentally:
https://www.smithsonianmag.com/smart-news/does-exposure-gree....