Ask HN: How do you create the website for your product?

Imagine this is pre AirBnB and you have the idea of building AirBnB.

AirBnB is not just a static website for which you could use some sort of CMS and or Wordpress kind of thing: it's a highly dynamic service, lots of API calls etc.

Do you build it by hand? Do you pick some front-end framework such as react.js/angular.js/vue.js, and some backend framework (nodejs+express, django, whatever..) and do everything by hand? Or is there something out there that I don't know about?