Comment by jokowueu | Hacker News Reader

Comment by jokowueu | Hacker News Reader

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I'm am glad you are helping your daughter thought this . This disease is such a cruel thing to have .

I would like to offer some extra info .

Since you are looking for OTC . Both NAC and SACROSINE have a lot of great research when it comes to schezophrenia. It seems to work for some but not others.also new research into TMG (betaine glycine) is also interesting

There is also a new drug on the horizon that doesn't work on the dopamine receptors and has much less side effects than what's currently

SEP-363856 helps treat negative symptoms of schizophrenia such as Inability to experience pleasure, Lack of interest in relationships, Lack of motivation. 5HT1A and taar1 agonist

https://www.medscape.com/viewarticle/913348

MIN-101 - a ~20% BDNF increase. Treats negative symptoms of schizophrenia. 5HT2A and sigma2 receptor antagonist.

Min-101 has a targeted release of 2021/2022. After they have completed their 12 week phase 3 trial, they will do a 36 week phase 4 trial. SEP, should also be available sometime in those two years as well.

Hope your daughter finds peace

I have a mutation which results in impaired BDNF and I do suffer from anxiety; so far buspirone seems to work, but I was considering SEMAX/SELANK for the BDNF increase, do you know anything about that?

I can tell you it'll make your hair fall out.

And maybe make you 20% less anxious/more focused, but honestly it's hard to say... actually, in retrospect I never experienced acute anxiety when I was experimenting with it. Certainly worth a shot.

Does the hair come back after you stop using it?

I already have moderate male pattern baldness :)

20% seems ok to me, buspirone is not that great either, but I never experienced panic attacks while on it(actually I only experienced panic attacks while on stimulants), and if I had another option like SELANK/SEMAX with the BDNF boosting bonus, that would be great.

I'll give them a shot.

I'm not sure but I think it's permanent. If you don't mind getting balder than you currently are, great.

Semax can make your hair fall out slightly selank doesn't . Ive heard good stories about both . Try them both out but start with semax . Do it long term .

Fasting can increase bdnf by 3.5 times . Research intermittent fasting and also long term fasting (48 hours) .

There is just so much that can increase bdnf but as a rule of thumb when it comes to herbs . Studies mostly are short term and just not as good .

I recommend coming over to the nootropics subreddit and research/ask there

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