The owners manual says that you can't shift to park if the car is in motion.
And it will automatically switch to park if the car is stopped, the drivers door is opened and the driver's seatbelt is removed (also when the car is switched off), so in that regard, it may be safer than a traditional shifter, it'd be nearly impossible for a driver to run himself over with his own car.
If the driver really wants to keep the car in neutral after exiting the vehicle, you can press N, then press it again and hold for 2 seconds.
I don't have a car with a push button shifter like this, but the reverse button is so distinctive that I'd think it'd be pretty easy to orient your hand and get used to pushing the buttons without looking.
I'm not sure if this shifter is on all of the Accords, or just the Hybrid, but in the hybrid there are no other driver gears, there's no transmission at all, just some clutches to connect the engine directly to the wheels or to a generator, or both -- the engine uses a fixed gear ratio when connected to the wheels, if the car is outside a speed the engine can handle, then the electric motor drives the car.