Fastmail
They do not compete on Privacy at all in my opinion. So then the choice comes down to price, features and economic viability of the organisation. I think price and features they are on par with Office 365, well at least for individuals not for enterprises.
But in terms economic longevity I think Microsoft wins hands down. Fastmail might be days away from bankruptcy, none of us would know as it is private company. I would rather have my personal email, that is the glue to modern life, with a Trillion dollar company than with a relatively new minnow.