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The GP obviously doesn't mean that 1000+ ppm CO2 is toxic, they mean that the changes to the environment it would cause are less than ideal for humans to thrive.

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1000ppm decreases human cognitive ability by ~20%. It's hard enough to deal with these problems with the brainpower we have.

[1] https://ehp.niehs.nih.gov/doi/10.1289/ehp.1510037

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