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Nicest for Python, I assume.

Many languages have FFI. Lua, PHP, etc. https://en.wikipedia.org/wiki/Foreign_function_interface

I don't understand the choice of Python for things like gluing together C programs. Seems like a performant mistake, at the very least.

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It’s the 80:20 rule, which naturally doesn’t always holds. Often, however, a small part of the code is responsible for almost all of the performance issues.

By picking the performance sensitive areas of the program to code in C one can often code the rest of the program in a slower more convenient language.

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