For every lifestyle decision, there are always potential risks and potential benefits.

For example, people who run excessively tend to lose fast-twitch/bulk muscle mass and wear their hips, knees and ankles faster than most people. For example, one of the worst things you could do to your body would be to repeatedly run fast, downhill while letting your feet slap the ground.

And, you're never going to be able to measure all of the pluses and minuses intellectually or quantitively, which is why these choices tend to be primarily qualitatively-based with some quantified-self bits on the margins.