Google will negate the click if they are seeing high bounce rates.
When a few publishers complain to their adwords representative that they get no conversions from your site a few flags could be raised. Such as a site audit by a Googler.
Make sure you monitor your adsense messages just in case.
In the end this is exactly what the big boys do....just check out statistics of facebook for example running ads on Google Adwords or Techcrunch or even Sears.
for one thing I'm not done testing nor will I ever be I don't need tens of thousands of clicks now as I did initially.