Would you consider this easy?

  # Makefile
  venv:
   python3 -m virtualenv --version 1>/dev/null 2>/dev/null || \
    ( echo "Please install virtualenv (python3 -m pip install virtualenv wheel setuptools)" && false )
   [ -d venv.d ] || python3 -m virtualenv -p python3 venv.d
   ./venv.d/bin/pip install -r requirements.txt

  $ make venv
  
  # Running your project without setup.py
  $ ./venv.d/bin/python3 my-program.py
  
  # Running your project with setup.py
  $ ./venv.d/bin/pip install .
  $ ./venv.d/bin/my-program.py

The setup.py you can copy from another project and customize to your liking.