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It's synthetic, so there's little reason to transport it cross border or long distance.

What's the difference between synthetic and manufactured?

I think the difference is between the one which you can grow Vs the one which you can synthesize.

If you can grow a drug then you need to move it if you can synthesize it locally then there is no need to transport it.

Synthesizing a drug has much smaller footprint so easier to hide the operation Vs growing some drug.

I'd say that manufactured covers all processes, so extracted from a plant is manufactured but not synthetic.