There's not much architects can do about what happens to buildings after completion. They no longer have a role in the life of the building. I don't think it's necessarily a very bad sign that they sometimes express disappointment or frustration or indifference about the way the building actually ends up being used. They aren't responsible for maintaining it, unlike the authors of software. It is out of their hands.
Every sane architect is OK with the fact that users will adapt their work.
"You know, it is life that is right and the architect who is wrong"—Le Corbusier.