I've been working from home for about 10 years. The only thing that's ever been a problem is maintaining a healthy work-life balance. It took years to realize and resolve all of the various underlying issues before I started feeling comfortable without being complacent with things.

My advice for people new to remote work: reserve an hour each morning for exercise, start reading fiction, try out the keto diet, avoid alcohol as much as possible, try to limit your caffeine intake, open your windows to prevent co2 buildup, keep eye drops within reach for long hauls, try to get all of your chores done in the morning.